CIP / SIP Systems for Pharmaceutical Applications
industries.
At Elettracqua, we design and manufacture CIP (Cleaning-in-Place) and SIP (Sterilization-in-
Place) systems specifically engineered for pharmaceutical, biotechnological, and cosmetic.
Our systems guarantee maximum hygiene, repeatability, and regulatory compliance, ensuring
safe and validated cleaning and sterilization of process equipment, tanks, and distribution lines.
Process Concept
The CIP/SIP process is an essential part of any modern pharmaceutical production line.
It ensures that all product contact surfaces are clean, sterile, and free from residues or crosscontamination,
without requiring disassembly of the equipment.
Elettracqua systems are designed to provide:
Fully automated cleaning and sterilization cycles
Precise temperature, time, and flow control
Optimized chemical and water consumption
Complete data logging and traceability
System Configuration
Each system is custom-built according to the user’s process, capacity, and space requirements.
Typical configurations include:
Single-tank, dual-tank, or multi-tank CIP skids
Integrated SIP modules with clean steam sterilization
Return pumps and heat exchangers for temperature control
Sanitary valves and instrumentation designed according to ASME-BPE and 3-A
standards
Automation based on PLC/SCADA with recipe management, alarms, and batch reporting
Systems are available in manual, semi-automatic, or fully automatic versions, with capacities
ranging from 100 L to several thousand liters.
Design and Materials
Elettracqua CIP/SIP skids are built in AISI 316L stainless steel with ASME BPE SF1 internal
surfaces (Ra ≤ 0,51 μm) or electropolished internal surfaces (Ra ≤ 0.4 μm)to minimize microbial
adhesion and ensure easy cleanability.
All wetted parts are made with FDA-approved materials, and all piping and fittings follow
ASME-BPE and GMPdesign guidelines.
Utilities and Integration
Our systems can be integrated with:
Purified Water (PW) or Water for Injection (WFI)
Clean Steam and Compressed Air
Chemical dosing systems for detergents or neutralizing agents
Return lines to drain or recovery tanks for solution reuse
Each installation is tested and optimized to ensure thermal, chemical, and microbiological
effectiveness of the cleaning and sterilization process.s.
Validation and Compliance
All Elettracqua CIP/SIP systems are designed and qualified according to:
EU GMP Annex 15
FDA 21 CFR Parts 210–211
ISPE Baseline Guides
GAMP 5 automation principles
Every unit is delivered with complete DQ/IQ/OQ documentation, FAT and SAT protocols, and full
traceability of components and welds.
Key Advantages
Turnkey design and manufacturing
Fully automated, validated cleaning and sterilization cycles
Optimized energy and chemical consumption
Modular and compact design for easy installation
Technical support and after-sales service
Discover the Perfect Solution
for Your Needs!
Our pre-treatment systems are custom-designed
to align with your chosen purification method
and specific water quality requirements